Brothers & Sisters. Emily VanCamp and Dave Annable, real life couple, played siblings (albeit half-siblings of the illegitimate persuasion) onscreen in this TV series.
Tyler Perry’s Meet the Browns. David and Tamela Mann, real life married couple, play father and daughter.
The Sopranos. Jamie Lynn Sigler and Robert Iler, caught fraternizing once, were onscreen siblings for years.
Gossip Girl. Blake Lively and Penn Badgley have played onscreen siblings (through marriage) as well as carried on an offscreen romance.
Dexter. Michael C. Hall and Jennifer Carpenter, onscreen half siblings, were married until recently when Carpenter filed for divorce.
Everwood. Emily VanCamp and Chris Pratt dated while playing TV siblings.
Lost. Evangeline Lilly and Dominic Monaghan play siblings in the tropics all the while heating things up offscreen romantically.
Parenthood. Peter Krause and Lauren Graham confirmed their rumored offscreen relationship while playing siblings on this new TV series.
The Boy in the Plastic Bubble. After John Travolta and Diana Hyland starred together in the aforementioned feature film as son and mother, they were romantically involved.
Lost. Maggie Grace and Ian Somerhalder reported dated while playing siblings.
Once and Again. Evan Rachel Wood and Shane West, who played brother and sister, were said to be canoodling all around town.
Ferris Bueller’s Day Off. Matthew Broderick and Jennifer Grey dated after filming this iconic feature film.
Heroes. Milo Ventimiglia and Hayden Panettiere dated while filming this TV series starring together as uncle and niece.
The Partridge Family. David Cassidy and Susan Dey played siblings during the run of this TV series and admitted sleeping together shortly after the series ended.
North and South. (1980s mini-series) Parker Stevenson and Kirstie Alley, spouses at the time of filming, played siblings.
Nip/Tuck. Joely Richardson and John Hensley, offscreen couple, played onscreen mother and son.
Dr. Who. David Tennant and Georgia Moffett star as father and daughter onscreen and are dating offscreen.
Firefly. Sean Maher and Summer Glau starred as Simon and River Tam on this TV series and were said to have briefly dated.
Parker Stevenson and Kirstie Alley on July 11, 2018:
kristie you deserve better .because i know!!!!
Jeremiah Sherrill from Springfield, Missouri on August 26, 2012:
You forgot Roswell
Jason Behr and Katherine Heigl
Heather on February 11, 2011:
That's hilarious. All the way back to The Partridge Family, LOL.